Seizure after withdrawal from supratherapeutic doses of zolpidem tartrate, a selective omega I benzodiazepine receptor agonist
نویسندگان
چکیده
منابع مشابه
Zolpidem at supratherapeutic doses can cause drug abuse, dependence and withdrawal seizure.
Zolpidem is a non-benzodiazepine hypnotic drug, acts selectively through omega 1 receptors of GABAA. It is thought to be safer than benzodiazepines but we report a case of zolpidem drug abuse, dependence and withdrawal seizure.
متن کاملZolpidem Dependency and Withdrawal Seizure: A Case Report Study
INTRODUCTION Zolpidem is a short acting inducer of sleep and thought to lack benzodiazepine properties such as anxiolysis, anticonvulsion, muscle relaxation and side effects such as dependency. Recently, some cases of Zolpidem abuse and dependency have been reported. In review of literature, we found that the lowest reported dosage of Zolpidem, which caused dependency, was 160 mg daily. CASE ...
متن کاملZolpidem dependence and withdrawal seizure--report of two cases.
Zolpidem is a non-benzodiazepine property which binds selectively to the ?1-GABAA receptors, and has been widely prescribed to patients suffering from insomnia. We report two cases of zolpidem dependence with withdrawal seizure in the Asian population. The first case is a 43-year-old woman who took zolpidem up to the dosage of 200 to 400 mg per night. The second case is a 35-year-old woman who ...
متن کاملComparison of the Melatonin Receptor Agonist Ramelteon and the Non-Benzodiazepine Hypnotic Zolpidem for Nocturia
To examine the efficacy of the melatonin receptor agonist ramelteon for nocturia, it was compared with zolpidem, a conventional non-benzodiazepine hypnotic. A total of 50 patients with nocturia (2 urinations/night) were enrolled. Subjects assigned odd numbers or even numbers were respectively prescribed 8 mg of ramelteon (n = 27; mean age: 75 years) or 5 mg of zolpidem (n = 23; mean age: 73 ye...
متن کاملzolpidem dependency and withdrawal seizure: a case report study
conclusions zolpidem dependency and withdrawal seizure can occur with a dosage under last reported doses. therefore, possibility of mentioned problems cannot be excluded at any dosage and physicians should pay more attention to potential of zolpidem to create these adverse effects. introduction zolpidem is a short acting inducer of sleep and thought to lack benzodiazepine properties such as anx...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 1997
ISSN: 0885-3924
DOI: 10.1016/s0885-3924(97)00017-1